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The human upright posture is considered to be the reason of the chronic venous insufficiency (CVI), which is the syndrome of impaired blood backflow from lower extremity veins. A number of factors contribute to the onset and progression of the disease: hereditary background, female gender, pregnancy, poor physical activity, excessive weight, etc.
The literature is abundant with experimental and clinical trial data about the horse chestnut and its chemically purified biologically active components. The seeds contain 30 to 60% of starch, escin, protein, fatty oils, sugar, catechine tannins. The leaves contain flavonoids (quercetine), carotinoids (lutein).
An important role in treatment of varicose veins is played by conservative treatment ensuring good results in the early stage of the disease when skin manifestations and disability are only moderate. There are two options of conservative therapy approved at the moment: compression therapy and administration of venotonic drugs.