Summary. Data on coexisting Graves’ disease (GD), hypoparathyroidism, and autoimmune hemolytic anemia are limited. Here we report an uncommon case of autoimmune disorder causing Graves’ disease with autoimmune hemolytic anemia and along with mineralization of basal ganglia. The patient had a parathyroid nodule along with normal serum calcium and parathyroid hormone levels. The probable cause of this nodule is a compensatory response to autoimmune hypoparathyroidism. Patient has increased levels of T3, T4, free T4, thyroid binding globulin and antithyroglobulin antibody. The ANA and anti dsDNA antibody were within normal limit. The relative deficiency of CD4+FOXP3+Treg cells in peripheral blood also confirms the autoimmune pathogenesis of the disease process. The patient responded to the steroid therapy and later on maintained with low dose carbimazole.
Key words: Grave’s disease, Hypoparathyroidism, Hemolytic anemia, Autoimmune disorder, Steroid.
The original article is published in JOURNAL OF CASE REPORTS 2014; 4 (2): 253-257
Published in the «International Endocrinology Journal» №1(73) '2016